My experience of the years of hunting I did with the .375 is that on deer, it possessed no dramatic advantage over many lighter calibers except possibly on the rear end shot. I used 300 Hornady bullets almost exclusively, and they open pretty quickly compared to some others.

The modern bullets you describe open fairly well but I will be interested to see what you think about the 300's and 350's on deer, vs, say, a .270, .30-06 or many other calibers. Stoutly constructed .375's may even allow slightly more runners on broadside lung shots on deer if the bullets do not open quickly enough or the range is long enough to allow the bullets to slow down a bit.

In general, on deer, I cannot tell you I ever saw any big advantage of the .375 over many lighter calibers. Finn Aagaard said similarly about the .375 on antelope of deer or somewhat bigger size, and others I've read over the years have agreed. On much heavier game, the .375 provides a certain edge in bonebreaking, depending of course on bullet used.

Some might take issue with this statement, but that is my experience. One thing I should add is that I do not think the .375 is a DIS-advantage on deer. It is a great caliber.