I have used it on Buffalo with 300 and 320 gr. bullets and in my 26" barreled gun it will run side by side with the great 375 H&H...I like the 320 gr. Woodleigh at about 2350 FPS with about 64 grs of H414 or 57 grs of RL-15, but these are max loads in my long throated chamber, so cut 5 grs. and work up....I use the same load for the 300 gr. bullets (Swift)