Tom, not the 200 Sierra, but one that is close. I have a load that shoots well in my .375 H&H that uses the Hornady 220 FP at 2450 fps, using 5744 powder. An added feature is that it shoots to same POI at 100 meters as my 300 grain full power load. I just bought some Hornady 225 SP's and plan to see how they shoot. Hornady can email you their loads for the 220-225 grain bullets.

I just called Hornady and they told me that the 220 FP should do very well on deer at my velocity, and the 225 is good for around 2300-2900.