I have used only the 416 caliber solids in my 416 Weatherby Magnum.
They are by far the toughest monolithic solids that I had tested. I recently shoot several bullets into an oak log to test their penetration and toughness. Rifle used - 416 Weatherby caliber, impact velocity - about 2700 fps. Those new Nosler solids performed significantly better than A-Square, Barnes, North Fork and GS Custom solids. Especially the North Fork and GS solids were badly deformed. But the Nosler solids showed almost no deformation of any kind. That was impresive to witness especially compared to the other solids riveted and the N-F being almost destroyed... But I suspect they will take the rifling downrange with them pretty fast... You want a tough bullet, you got to sacrifice the barrel, there is nothing for free... Besides the toughness they provided also the deepest penetration among those solids.
In my rifle they were not the most accurate bullets, but enough for DG work. I realy don`t expect match grade accuracy from a 416 caliber solid but toughness and penetration and they provide that aplenty. They have a small flat point and a truncated cone shape of the nose. That should give them good penetration in bone, but less penetration in living flesh, as you need a wider meplat for that. But I personally think they are well balanced. But to prove that I need to shoot some tough animals with them first. But in oak wood they were exemplary.