Based on the game you are hunting and where you plan to hunt them -Namibia.(where shots tend to be longer) -- I agree with the above and go with a 270 gr bullet..one of tougher design like a Barnes Triple or Swift A-Frame loaded--have used them both in my Sako and they shoot well..also in the smaller stuff--duiker, etc..I have shot them and not entirely messed up the cape for mounting later..-if you are stuck on the .375..

Personally having been there myself--If I was just hunting plains game I might consider taking a bigger flat shooting caliber like a 338 Ultra-mag with 250 gr bullets...

Ripp