I took my takedown 98 to Africa a couple of months ago and from a packing and transport perspective then I highly recommend it.

From the switch barrel/caliber point of view however I don't think it is worthwhile.
A switch barrel is going to be limited by the ability to re-zero the scope for the caliber change or it must have a specialised barrel mounted scope. If the barrels only have open sight sets ( to avoid this ) then any advantage will be mittigated by the size of the coverage of the foresight at any given range. I think that it would be better given the expense to spend the money on ammo and learn to shoot the 416/404 well at extended ranges.

If it is a bolt action and DG is on the menue I would fit claw mounts and a good set of express sights on a 416 or 404 and shoot plains game with the scope and take it off if one were stalking DG (up to but not including Ele).
A 404/416 class is more than accurate enough for PG out to 200 yards which IMO is far enough as I am not a fan of "sniping" at animals.

If it is a double then I would like a set of barrels in the 9.3/375 class with a scope and a set in the 450/470/500 class with express sights for Ele or buff if specifically stalking them only. If Ele were not on the menu then I would be happy taking anything else with the 9.3/375.

IMHO if one is shooting specific species that will require due to terrain (ie Springbok in the desert) 200 yds + shots then a seperate flat shooting rifle designed with this in mind should be used. 7mm mag, 300WM, 8mm mag which could be zeroed at 200 givin point blank trajectories out to long range.

Now if the makers of scopes are reading this!! I would like a scope with a fine cross hair and then a red dot or second illumintated reticle that can be turned on and zeroed indipendently of the main cross hairs. That would make a switch barrel gun a real versitile possibility.

Regards