Ok,

We now know that cape buffalo hunting is becoming theoretical and I probably will never have practical experience, so I'm going to pontificate on the virtues of the 450 3.25 NE at the expense of the 450/400.

5000 ft/Lbs kinetic energy versus 4000 ft/Lbs, .458" versus .411, Do the math gents. The 450 delivers 20% more energy but only 20% more recoil.

The 450 shoots the 350, 400, and 480 grain bullets very well giving it a wide envelope.

Objectively, I say the 450 NE is superior to the 450/400.