Showing my ignorance--

It would appear that the top right would be easiest shot to screw up vs the anterior angled head on shots--

If you shoot abit back and too far ABOVE the top 1/3 of the chest or BELOW the "mystical" 1/3 up from the bottom of the chest to the opposite shoulder there could be problems. I assume there may be trouble with not getting the vital cardiopulmonary structures.Hopefully both lungs would still get hammered but how far up or down the actual shootable margins extend could be is a guess for me.

The question arises how low is too low or high is too high??
A buffalos lungs are a large area to shoot at.
Don't think I want to find out in Africa.

Obviously whacking the middle 1/3 of the chest through to the opposite shoulder to break 'em down as shown is the money shot!

On the anterior angled shot the trick is to angle the shot for both lungs/heart.Years ago had a friend shoot at an elk's middle chest on an angled anterior shot and only ONE lung was hit.
That was a long day-- With a cape buffalo that would be a disaster.