To give some idea of the value of muzzle energy as an index of killing ability, consider an old black-powder load for the 45-70 and a modern load for the 22-250. A 405 gr bullet at 1334 fps and a 50 gr bullet at 3797 fps each give 1600 ft. lbs of energy. Which would you prefer for hunting American bison?

Okay, they have the same muzzle energy. Which one has the most "killing power?"