Stellenbosch University would have to be in a very safe (and expensive) area. It actually fills a lot of downtown Stellenbosch in the centre of the city.

For tourist visits from my trip there last year, the Wine Regions of Cape Province are pretty safe, Stellenbosch, Paarl, Tulbargh (lots of heritage and old colonial buildings), Frankshoek (splg?) - the location of settlement for a lot of French Hugenots, and Constantia (in Capetown).

Knysna (proonounced "NIsna") is a Port city on the South Coast which was fairly safe. Lots of tourists. We even went on a tour of the township, but it was a tour not self-guided. They even showed us where they had "battles" with the Afrikaaners and drove the white residents out of the township.

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I actually tried to get a graduate exchange to South Africa through the AIESEC organisation (Business and economics students) after graduating from University in the 1980's. Got offered something but turned it down. Back then it was of course a big NO NO. I met with previous participants and it sounded like a great experience. Unfortunately it did not work out for me to go to South Africa or elsewhere in Southern Africa.