I agree with Marrakai as well.

Lighter weight high velocity bullets are great fun and can be shot long distances for kills but have variable penetration that cannot be reproduced in tougher animals.I feel penetration to the vitals and hydostatic failure(shock) is what ultimately puts animals down.I think "Hydrostatic Tissue Energy" delivered to the tissues with non CNS shots is BS- this is really just the nervous system of certain animals transiently collapsing reacting to bullet trauma with non CNS hits. Ultimately all animals must loose B/P with circulatory failure to stay down.

Adrenalized animals are completely different. If adrenalized tough critters are not hit mortally in the CNS you got real problems cause they can go up to 5 minutes with no B/P at all--plenty of time to kill you!!

No. 2 is unreliable for the big stuff.
I vote for No. 1.

I think standard velociies with heavy for caliber deeply penetrating bullets are the way to go. Momentum with adequate energy delivered in the rightplace kills 'em consistently every time.