Both 1 and 3.

Not 2 as I have found from testing (on Buffalo)
that lighter bullets just do not penetrate as far.

Issue with 3 (350 grain .375 H&H at 2200 fps.
) is it gives / shortens the Point Blank Aim
alot - so long shots may be a problem but then again,
if going after longer shots, have 300 gr Projjies loaded.