My first Elephant was in the Doma area of Zimbabwe and I tried a brain shot with a 375. Was high ,Elephant went down and IMMEDIATELY back up. PH was slow with followup shot, and as Elephant wheeled I put in a heart/lung shot, again probably high. Elephant made it back across park boundary and I paid for a lost Elephant. Quite a bit of blood where Elephant stopped after about 150yds so was probably fairly well hit but still lost. As a result I have not tried another brain shot.