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I guess I am trying to validate a qd scoped 450/400 as a primo setup for a mixed bag DG hunt vs the usual 375/416 bolt choices. Sounds appealing anyway.I am sure someone has done this previously.Was it 450No2? Is there a devils advocate out there to shine light on any problems?

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If you are looking for someone to tell you, yes you have to do it, I will.

A scoped .450/400 would fit the bill quite well. Most plains game is shot under 150 metres, and a 400 gr .400 will do it very well. And a good starting calibre for a double for dangerous big game hunting as well.

.450NENo2 is a great advocate of the 9.3x74R, the .450/.400 and the .450 No 2 Nitro Express doubles.