I guess I am trying to validate a qd scoped 450/400 as a primo setup for a mixed bag DG hunt vs the usual 375/416 bolt choices. Sounds appealing anyway.I am sure someone has done this previously.Was it 450No2? Is there a devils advocate out there to shine light on any problems?

A scoped 500/416(a close 416 bolt equivilent) would be fun if accurate as well but who wants to carry the extra weight all day?

The 375's record of problems with Ele encounters is indeed concerning.In DG country you gotta believe in your PH for firepower in addition to your rifle.