I've taken a 375H&H and a 458 DR and been happy. I would love a 375Flanged Mag DR as a second rifle but the bolt works great.

I don't agree with Marraki about the bore and stopping elephants. But if you are not hunting elephant or buff you will be carrying your light rifle any way. If the country is relatively open I keep a soft up the spout of my 375 and a soft on top in the magazine. If the country is thick and there are lots of elephants then the soft up the spout and all solids in the magazine.

.458" solids work great on buffalo, but you should follow your PH's recomendation. The PH with whom I've hunted buffalo prefers all solids. I've killed four buff, all with solids and they work fine. I wanted to try a 500gr Woodleigh soft on a buff this year but the buff we wanted we found while on elephant tracks and the softs were in the truck.

Your DR should be up to 200 yard shooting I think. I don't shoot that far with mine, but that doesn't mean it isn't up to the task. If it will shoot well with a scope it should be fine. I killed a klipspringer at 75yds with my rifle this year. A klipspringer is a tiny antelope. I'll try to post a photo tomorrow.

JPK