I would guess that 90% of shots at cape Buffalo (not sure about water Buffalo) would be around eighty meters give or take ten meters, and knowing that many hunters can not shoot as well as they should, plus hunting conditions at the time, I would think it is a risky shot.
Last year we watched an upset hunter and PH return to camp for three nights after tracking a wounded limping Buff that was hit with a Tungsen tipped 416 solid in the chest front on.
On first hearing of it my PH knew exactly what had happened and said this is not uncommon with such a shot.
PS; the hunter never recovered his Buff and was shooting with open sights.
ozhunter