NitroX - Good post and well said.

The following relates to Water Buffalo

338 Win Mag 2 Bulls and 1 Cow
A bit light for Buffalo as I had been told by PH's
before but had it in my hands at the time. I tend
to agree that 338 is not enough gun.

9.3 x 64 M98 Mostly cows and smaller bulls
250, 286 and 320gn Protected Point SN and RN
250 is definately a bit light on, 286 and 320gns are fine.
Bullet placement always a factor. Normally 2 shots but
I tend to keep shooting.

375H&H Multiple Large Bulls, cows and smaller bulls
(Some cows can be quite large !!!)
270, 300 Protected Point SN and RN
Great calibre, kills when put in the right place

450/400 / 404 Mostly cows and smaller bulls

500/465 / 470 Nitro
Large Bulls, cows and smaller bulls
Great calibres, Kill well all of the time

500 Nitro / 505 Gibbs Multiple Large Bulls, cows and smaller bulls
BIG difference between 470 and .500" + calibres - you can see the shockwave
travel along the body after being hit.
505 Gibbs with 600gn Bullets over the 525gn

I prefer Bullet placement over velocity any day of the week having
shot quite a few animals with the same round / bullet at different
velocities

Favourite gun / calibre

I like hunting with Doubles so my Westley Richards 500/465
which has 23" barrels and my Westley Richards 500 Nitro
which has 22 inch Barrels.

Bolt Actions - my Jeffrey 375H&H as it fits me well and I can
shoot it and reload with it very quickly.

For Nostalgia reasons, my Original 505 Gibbs Magnum Mauser

500 Nitro