While I think the 300 is a perfect pairing for Bulldogs 375, I agree that the 338 is one SUPER cartridge.

If I were to leave for Africa today, for a mixed bag hunt, I’d take my 338 Win Mag, and
my 458 Win Mag (both pre-64 70’s).

Both have the same ergonomics (bolt manipulation/stroke and safety). Both classic American/Win rifles in Win Mag chamberings. And they’re just a step up (power wise) from the excellent 300/375 combo.

What I personally like about my choices:
458’s stopping abilities compared to the 375 if things get dicey.
338’s stopping abilities if a plans game hunt/outing unexpectedly turns into a dangerous game hunt (or just the need to defend oneself against DG).

The 338 is “the” most versatile cartridge in my book…. 180’s, 200’s, 210’s, 225’s, 250’s, 275’s, 300’s (and the 250 and 300 can be had in high SD solids!). Check out the SD’s for the premium 250’s and 300’s…… I don’t think penetration would be an issue on the big stuff….and with a lighter, high BC bullet, long range performance is fine (power and the ability to place bullets accurately).