I have not shot game with 350's in the .458 win mag, but on paper the groups were about 6 inches higher than 500's were. I have shot game with the 400 grain Woodleigh PP and it was excellent. However, I see no reason you could not shoot PG with 500 grain bullets, or even compromise with 450 grain bullets so that you do not need to worry about 2 points of impact.