Back in the 70's, I fired one shot from a .500 Barnes Supreme form the standing position. I thought I was ready for it, but no, I wasn't. I'd been shooting my BRNO .375 H&H from the bench and although it didn't hurt at all, I reveled in it's "power".
That shot from the .500 spun me around like a weathercock and I almost lost purchase on the forend. Should have held tighter, I guess. I went up to the clubhouse and drank coffee until my shoulder's pain subsided then went back and resumed shooting my .375. It felt like a .222.
I put over 15,000 rounds through my .458's. Although only in 2" cases, they ran current .458 Win. Mag. factory vel. For example, 2,300fps with 400gr. and 2,060fps with 500's. I didn't think it kicked that much, but accumulative damage resulted.
Those 15,000 rounds severely damaged the cartilage in my right shoulder to the point where, back in the early 2000's, I couldn't shoot anything heavier than my .17 cal. wildcat gopher rounds.
Just because you can, doesn't necessarily mean you should. I which I hadn't. Of course a little moderation on my part may have alleviated the developed problem, mind you the damage occurred over many years of testing this ctg. Shot a bunch of grouse, coyotes and a few moose with it.