I have killed Cape buffalo with both my Krieghoff Teck O/U .458 WM double rifle and my wildcat .505 SRE, and I prefer the .505 for the more emphasis it brings to the table. I once killed three buffalo with four shots in less than three minutes. That's the kind of performance I respect.
My .505 is loaded with Kynoch 570 grain solids meant for the .500 Nitro Express and the load I use duplicates the .500 NE performance: 570 grain bullet at 2150 fps. The rifle weighs 8.75 pounds and I could carry it all day. Its weight matched almost exactly the weight of the M1 rifle I was issued when I first joined the Marine Corps in 1960.

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