I believe the 375 Ultra would shine in a 350 gr or 380 gr bullet. You don't have to always go full tilt to get the best performance. Since Jon Sundra first wildcatted the 300 Ultra to the 375 Ultra, I've always wanted to have one. He decided back then that going full tilt wasn't going to make it any better; he backed it off by a 100 or 150 f/s or so.