Personally I don't see the use of pushing a 300 gr bullet faster than 2500 fps in the 375. And if I wnat to go fast and flat with the 375 I go for impala bullets 200 gr @ 2900fps - 3000fps or barnes 210 gr @ 2800 fps. Fast enough to shoot any big critter at 300 meters comfortably.

This is just my feeling about it anymore speed and you get more recoil and more flinching anyway.