I don't have experience hunting dangerous game, yet. I do have a 458 Lott set up and am getting ready to build another heavy off a TGR-S action I lucked into with a 1917 enfield in the wings. I think the ideal set up for a DGR would be a Trijicon Reflex sight. I have a Leupold Gilmore 4 MOA reddot on my Lott and it works great but you have batteries to deal with where my Reflex (also 4 MOA)is tritum powered. Both sights are rated for all calibers (Reflexes are mounted on MK 19s and M2s in the military) and are ideal as you keep both eyes open. I will have my Sako set up with a rear leaf that I can see through the Reflex (just like my M4 sights can be seen through the optic) so if for some reason the dot goes away the irons are visiable without removing anything. The Reflex and Reddot scopes are the fastest sight set up there is, that is way the military uses them for CQB. I have fired four rounds out of my Lott as fast as I can work the bolt on numerous occasions and the Gilmore works like a champ.
Jason Connerley