I had great success with my .375 H&H. I was handicapped in no way. Distance or too large a caliber. 4 shots and four game animals in various terrain. Large old Impala, good old warthog, red hartebeest at 200 meters and a large stallion zebra. Of course all shots were well placed, 300 gr Woodleigh SP RN.
I would have been equally armed for this game with my 9.3x62 with 286 gr similar bullet. All other shot were no more than 100 + or minus meters.