Against my better judgement, I "allowed" my son to take his .280 Rem. to Africa to hunt plainsgame. He was and is not into shooting like his old man, so punishing him with a .375 was too much, and I gave in.

The .280 (like a 7xx57 on speed) worked fine except on a sable that should have dropped but didn't. We found it dead not far off, but a .375 would have dropped it in its tracks. I don't think you can made little guns into big ones, regardless of bullet weight, type, placement, or history.