It is a tough one.
What caliber and what game ?.

A lot of things to concider as in type of animal,type of country and if you have a PH or mate with you.

I am torn between "use a gun that will work when everything goes wrong" to being confident to use my 8x68 and 9.3x62 on anything bar Elephant on a paid hunt with modern bullets.

It is like a 9.3x62 is about the smallest caliber anyone would use on Cape Buff (I know 375 is min in some counties) but a 338 Win mag is a no no.
300 grain Woodleighs and 275 grain A-Frame 338's are every bit as good as a 9.3 imo.

Will be keen to see the replies as well.