bonanza;

I've used the 225 Horn {resized to 9.3 cal} and the 270 Horn {in .375 Mag and resized to 9.3 cal} on a variety of game; WT deer, impala, zebra and a wolf-crazed-wild steer and they work great. If your .375 likes the 225 Hornady, I think it is a real winner. I haven't found a super load for my .375 yet, tho the old barrel is working on 3000 rounds so I'm not sure if that is going to happen.

I've also used the 300 Hornady RN on elk, WT deer and a big blue wildebeest and other smaller stuff and it, too is a great bullet for such.