Most hunters shoot some of their bait which is normally Zebra (a biggish animal) and also take other game on the same hunt so maybe something a little more versatile is in order.

Even from a blind you maybe required to shoot through some bush so a slightly heavier pill may be more reliable.

I'm only being the devil's advocate. ....I'm Sure theres been heaps shot with .243's,.270's and 6.5.