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If only one "big" bore rifle, I'd go for the .375 H&H Magnum. The original "one world rifle".

Can at a pinch be used for medium range hunting, with a similar trajectory to a .30-06.

Can use lighter bullets for medium game hunting.

Will kill everything up to and including elephant.

I shot my one and only cape buffalo with a .375 H&H Mag. Will be fine on scrub bulls too. And the calibre produces good results on water buffalo too.

A BIG advantage to a UK resident is .375 H&H Mag ammo is reasonably easy to buy at a reasonable price. So if you are limited to FMJ ammo in the UK for "target" shooting, it might be possible to access suitable ammo such as Norma for good hunting ammo.

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It's good to hear that the 375 will do the job, one ends up believing game is bulletproof by hanging around on some forums....