Boy, that's a tough order to narrow it down to one caliber

. My personal favorite is the tried and proven 375 H&H but blown out to the Ackley Improved version:). The reason I went up to the 375 is because plains game encompasses such a variety of animals from the smallest Duikers up to the large Eland. I like 2 large holes in any game I shoot, and with a good bullet, the 375 is up to the task.

There are, of course, many excellent calibers available that will take care of 95% of plains game with no trouble at all. It comes down to putting a good bullet in the right spot with the first shot.