I shot my buffalo with a .458 lott and was quite pleased with it's performance. My motto is use enough gun. I don't fancy the idea of taking on a wounded cape buffalo with a marginal caliber. I put myself at risk, and the PH and trackers. Maybe even nearby rural africans if it gets away. I like the idea of a heavy rifle in areas where you are likely to encounter elephant and lion. No matter what caliber the best possible bullet is the one to use. I used the Swift A-Frame and Hornady solids in 500 grains. I shot a heck of alot and felt confident with the rifle. As to shot choice I can say this. Hunting is a sport that requires gut instinct and split second decisions. Seldom are shots perfect textbook broadside presentations. There is no substitute for proficiency with your rifle. Good hunting!