A 375 H and H is better ,because you get better value for money for your hunt, you can shoot the buffalo 5 or 6 times before it falls over, unlike a 500 which might only take one shot and its dead and feels like a instant anti climax ,plus the PH can join in the fun like a Mark Sullivan video where they are both blazing away at a buffalo running which has no apparent effect on it with the legendary 375 H and H , you also get an exciting follow up on a wounded animal .It doessnt kick much ,easy to get ammo for ,and more fun ,if i can just find a Colt Sauer with two magazines then i will sell my 500