Again, with no experience, I've always imagined my first shot at a Leopard to be with a 180 grain Accubond from my .300 Wby, and my first shot at a Lion to be with a 250 grain Nosler Partition out of my .340 Wby. Where the laws demand a different choice, I'd go with a 300 grain Partition out of the .375 H&H, or a 400 grain A-Frame from the .416.