I also shoot a .340 Weatherby and it is one of my favorite all-around calibers. The .340 is without a doubt enough rifle for any plains game animal and most others as well. A 250 grain bullet in a .338 caliber is an absolute marriage made in heaven. Period. The sectional density makes it nearly unstoppable when combined with a premium bullet. I shoot the Nosler Partitions but just ordered some from Conley Precision loaded with the 250 grain Accubond.