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I have not shot anything with the 577 NE but I have shot 1 elephant and 1 buffalo with the 585 nyati (750 grain .585" bullet at 2250 fps). Penetration with solids was 3 to 3.5 feet. In comparison with my experience with the 500 NE, the 585 Nyati seems to transmit more shock to the animal when taking a body shot. But I am not convinced it is worth carrying the extra 3 to 5 pounds of rifle for that extra shock.

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