Paul - just found John's (NitroX's) 2004 thread over at AR:

Quoting:

"The following photographs illustrate the aiming points to the brain and spine if shooting a buffalo from the front when he is facing you.

Bullet path when aiming for tip of nose (imaginary, starting point of red line in photo). Lower shots will either hit brain or spinal cord if centered.

Note how a shot from the side can not enter attempt to reachthe brain due to the position of the down swept horns.

Bullet path when buff has head lowered, in normal position

Three different bullet paths when buff has his nose in the air. Top one will probably miss brain (dark area). Notice cellular structure of upper skull, similar to that of elephant."