Well, I am going to Zimbabwe in september to hunt buffalo rather than lion. However, due to the chance of bumping one of the big, nasty, or carnivorous animals in the region I have opted to take a .375 ruger as my light rifle and .458 lott as my primary buff rifle. I based my decision on advice from guys in this forum that have extensive experience in dangerous game hunting. I have always sunscribed to the "use enough gun" parable. I will say that I have had to do alot of reloading and practicing to get to the point where I am confident I can deliver the shot where I want it to go. The .338 winchester was one of the choices, and mine shoots very well. I just think the .375 will do everything the .338 will in this case, and can fill in in the unlikely event my .458 fails or breaks. By the same token I feel sure I can take all the species I want with the .458 as well. Whatever your choice I wish you luck and a great hunt.