I had a chance a year ago to shoot a .460 Weatherby Mark V. I just don't think that many can imagine what an experience that can be. I don't care how effective or ineffective the round may be it is brutally recoiling. I'm sure that in the case of an emergency, a PH would and could use the rifle with little of no regard to recoil... but I can think of no better way of destroying shooting skills than regularly shooting a .460 Weatherby. As a hunting caliber I can think of any number of cartridges that would be more practical. For a PH who regularly has to pull the fat from the fire, it is probably OK... but how many guys like that are there in the world?
I've never shot a 500 but again, what is the point except for a once-in-a-lifetime elephant? And for a hunter, why would you want such a cartridge when so many lesser recoiling calibers exist that are perfectly adequate (at least I'm told so) for dangerous game?