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So, now I am thinking a scoped 375 H&H for the medium and the 458 Lott for the heavy.

Mostly, I am thinking this, so that i can use the 375 with Solids for croc and, if i have to take it in the water, hippo.

Do people typically shoot the croc and hippo with solids? If so, would 250gr solids from my .338 be legal and sufficient? I don't know if I can get them to pattern with my softs, but it might be worth trying.

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Do what you will--personally both would work fine--as to solids--I am hunting hippo next week in Zim and will be using a custom in .416 Remington--I am taking a 300 Ultra-mag I loaded with 200 gr A-Frames--out of my HS Precision--went out yesterday and proofed the load a final time--first 3 shots--just a tad under 1/2" at 100 yards--so went home and loaded 60 for the trip--which, if I shoot the hippo in the water will probably use that gun and will also use it on croc...your 338 loaded with 225 or my choice 250 gr bullets will work fine on anything over there including buffalo however because of legal requirements you would be restricted in most countries to a .375 or larger on dangerous game..--if the hippo is on land--solids out of the .416 is what I will use..

The one advantage you have with the .375 and 416 battery is that if one went upside down on you -you would have another at your disposal that can be used for either plains or dangerous....

Fortunately no matter the choice --you'll do fine..and you are going to AFRICA...