BIGMAX
Do what you will..I am leaving for Zim in 3 weeks and will be taking a custom .416 and a .338 ultra-mag..for plains game etc...this will be my 4th African hunt so I have chosen the calibers based on what I will be hunting as well as what I have experienced there previously..

If you feel perfectly comfortable shooting the .375 a lot then by all means take it however based on the game you described, again I would take the 338 or possible even the 30-06---as they will be a bit flatter in the off chance you need it...

Good luck on your hunt--you should have a blast..no pun intended..

Ripp