I have two 338's.I have seen a friend kill both a Cape buf and an Australian buf,with his 338.With 300 gn bullets I seriously doubt you could tell the difference.I killed my first water buf and cape buf with a 378 Weatherby and it did not seem to be much different to the 338.I feel all are on the light side for the foot stalker.The last three I killed were with a 500 nitro