I was once in a situation where I shot three buffalo in rapid succession out of a herd of about 40. This was on the advice of my PH, who kept seeing bigger and bigger horn spreads each time I shot. All three ran off after the shot and when the dust cleared we were faced with the prospect of following up three wounded bulls. As it turned out, only one required another shot, and that was questionable. I was shooting my .505, and did not feel in the least overgunned.

The results can be seen at http://www.frappr.com/?a=viewphoto&id=3823381&pid=6889796&myphotos=1

PS That is not my .505 I was holding. It was my Krieghoff .458 which I had just used to adminster the follow up shot on the one I was sitting on.