The only shots on big game I have taken beyond 300 yards have been with Barnes X and Accubond bullets. I have been very pleased with the performance of both bullets and would use either again.

Unless you are going to be shooting at distances well in excess of 300 yards, I would simply load up some of your preferred bullets and try them on paper at different distances. That approach is far more reliable for determining real-world performance of the bullet than any other theory or speculation.

At any shot on game past 200-300 yards, the ability of the individual shooter will impact a lot more on the outcome than most bullet designs.