Robie... I agree with NitroX that both cartridges are about the same. My personal favorite would be the .270 Win using 130 gr bullets for light boned game such as antelope and 150 gr premium bullets for the larger game. The 150 gr Nosler Partition, Failsafe, BarnesX or Speer Grand Slam would give you very good penetration from any shot angle. My personal favorite is the Nosler Partition that I have used for the last 26 years in 6 different calibers with very good success.