IMO, as far as suppository guns go, the .338 WM made all other calibres obsolete. Best all around calibre (for North America). Doesn’t mean I don’t like/appreciate my .500BPE or 45-90 but if I had to be limited to one hunting centerfire calibre it would have to be the .338. My Ruger #1 in .338 has killed a LOT of game and everything I ever pointed it at fell over and I can only recall one instance where more than a single shot was required. Now, having said that, I no longer hunt with mine as I hunt with muzzleloaders and intend to use my .500 once I get a satisfactory load for it.