LOL. 15,000 rounds of .458 did my right shoulder in. I'm still shooting the .375/06IMP at a little better than 1912 .375 H&H ballistics, though.
It's quite manageable with the muzzle break, tuned to 300gr. at 2,472fps.
It does OK with 270's at 2,650fps as well.
That's my little deer rifle.
For big deer, I use the 14 bore.