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It all depends on the scenario when hunting and how amped up there are before the shot..

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Or if the shot wounds it, and then a follow up on a worked up and angry cape buffalo is required. Then the .45/70 carrier will wish much for a better rifle.

I think I am going to start pushing the .577/450 as a great buffalo rifle. Same class as the .45/70.

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I was thinking the 6.5 Creedmoor could be a good useful all around caliber in Africa??

Chuck Hawks article below .. to further the discussion.. or not..
https://www.chuckhawks.com/rifle_killing_power.htm