Ripp
Most people I see use the 375H&H and usually it works out just fine. I took out a couple for a cull hunt that shot 50 odd buffalo with a 223 and 308 with zero problems. 375 H&H is my choice for most folks as it is a balance between power and usability. But I have seen some flinches from hell and think that is the biggest issue. At the start of the hunt we go to the range and fire a few shots and it can get quite touchy. Especially when someone uses our rifles and wants to adjust the scope because they barely hit the target at 75 yards or the groups are all over the place. I always have two shots before I adjust the scope and it can cause some tension when I put them an inch high and dead centre. Add in shooting sticks, a bit of excitement and some nervousness and it can easily go wrong with any cartridge. Just has happened most with the 375 because that is whats used most. I have also seen shots from 416 and 458s that should have been fatal just cause some mild level of annoyance. Some times more comes into it than cartridge and projectile. I think the situation the animal is in when it is shot can have a huge effect especially on bigger animals.